Isolation of Nalorphine Ethereal Sulfate and Nalorphine Glucuronide from Urine of Cat and Rabbit

Abstract

Isolation of a major metabolite of nalorphine from the urine of the cat was accomplished. This metabolite was nalorphine-3-ethereal sulfate by chemical synthesis of the compound. Evidence is presented to characterize the crystalline metabolite isolated from the urine of the rabbit as nalorphine-3-glucuronide.