The IgG receptor: an immunological marker for the characterization of mononuclear cells.

Abstract

Using red cells sensitized with an IgG anti-Rh0 antibody, an IgG receptor was demonstrable on human monocytes, hepatic macrophage and splenic macrophage preparations. The receptor was uniformly lacking on lymphocytes, lymphoid cell lines and lymphocytes stimulated with phytomitogens in vitro. The integrity of this receptor was demonstrated on monocytes obtained from patients with `acquired' agammaglobulinaemia, chronic granulomatous disease and acute monocytic leukaemia. There was no direct correlation between the presence of the receptor and the fine structure of the cells studied. It is proposed that this receptor is an immunological marker for identification of mononuclear cells.