THE RESYNTHESIS OF PHOSPHOCREATINE AFTER MUSCULAR CONTRACTION

Abstract

The early stages in the recovery process after muscular contraction were studied in the muscles of cats and rabbits. Lactic acid removal and phosphocreatine resynthesis proceed pari passu in the early stages of recovery. The amt. of phosphocreatine resynthesized in a given time is equivalcnt, in terms of base removed, to the amt. of lactic acid concurrently removed. The resynthesis of phosphocreatine from its hydrolysis products after contraction proceeds at a rate only a small fraction of that required by the Lundsgaard hypothesis. The reconversion of hexosephosphate-P to phosphocrcatine-P is slow during the early part of the recovery period.