Comparative effect of heparin and other agents on traumatic shock in the rat

Abstract

The effect of heparin and Aureomycin on Noble-Collip drum shock in rats was compared with that of autonomic blocking agents. Intravenous Dibenzyline (0.5 and 1.0 mg/kg) and Mecamylamine (2 mg/kg) notably reduced mortality when given 15–30 minutes prior to drumming. Heparin (2.5–10 mg/kg) and Aureomycin by mouth (150 mg/kg/day for 3 days) had no effect on mortality. Repeated sublethal trauma induced marked protection against drum shock. Concurrent administration of Dibenzyline did not prevent the development of this resistance. Repeated nonspecific stress and exercise failed to protect rats against drum shock suggesting that the development of ‘induced resistance’ is not related to elevated plasma catechol amines. The increased mortality of rats to drum shock incident to reticulo-endothelial blockade was mitigated if Dibenzyline was injected before blockade although not if given after.