Acetylcholine acts on m2‐muscarinic receptors to excite rat locus coeruleus neurones
Open Access
- 1 August 1985
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 85 (4), 733-735
- https://doi.org/10.1111/j.1476-5381.1985.tb11070.x
Abstract
Intracellular recordings were made from neurones of the rat locus coeruleus in vitro. Acetylcholine increased the firing rate by depolarizing the membrane; both muscarinic and nicotinic antagonists partially reduced this effect. In hexamethonium, pirenzepine shifted the acetylcholine dose-response curve to the right with an equilibrium dissociation constant of 200 nM, indicating an interaction with a m2-type of muscarinic receptor.Keywords
This publication has 13 references indexed in Scilit:
- Muscarinic M1 and M2 receptors mediate depolarization and presynaptic inhibition in guinea‐pig enteric nervous system.The Journal of Physiology, 1985
- Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterizationLife Sciences, 1982
- Electrophysiological properties of neurones contained in the locus coeruleus and mesencephalic nucleus of the trigeminal nerve in vitroExperimental Brain Research, 1982
- ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORSBritish Journal of Pharmacology, 1980
- Pirenzepine distinguishes between different subclasses of muscarinic receptorsNature, 1980
- A COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE‐SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA‐PIG ATRIAL PACEMAKER CELLS AT 29°C AND IN ILEUM AT 29°C AND 37°CBritish Journal of Pharmacology, 1976
- Binding of agonists and antagonists to muscarinic receptorsJournal of Supramolecular Structure, 1976
- The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea‐pig intestineBritish Journal of Pharmacology, 1968
- SOME QUANTITATIVE USES OF DRUG ANTAGONISTSBritish Journal of Pharmacology and Chemotherapy, 1959