Effect of Mouse Epidermal Growth Factor/Urogastrone on the Functional Maturation of Rat Intestine*
- 1 March 1983
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 112 (3), 940-944
- https://doi.org/10.1210/endo-112-3-940
Abstract
Mouse epidermal growth factor/urogastrone (EGF/UG), administered sc in a dose of 0.1 μg/g BW twice daily for 3 days, increased intestinal weight per unit length, lactase specific activity, and net calcium transport in normal 2-weekold suckling rats, but had no effect on maltase or sucrase specific activity. In normal 3-week-old weanling rats, the intestinal function of which is essentially fully mature, EGF/UG had no effect. These results suggest that EGF/UG, either secreted endogenously or ingested in breast milk, may have a role in both the morphological and functional maturation of the suckling rat intestine.Keywords
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