Acute Renal Failure Caused by Aminopyrine

Abstract

AMINOPYRINE is one of the more potent of the nonnarcotic analgesics and antipyretics.¹ Its once extensive use has diminished markedly because of its toxic effects on the bone marrow which produce leukopenia, neutropenia, and agranulocytosis, and sometimes result in death.² In a special report of the Council on Pharmacy and Chemistry of the American Medical Association published in 1934,³ the indiscriminate administration of aminopyrine was discouraged except upon strong indication and under medical supervision. Since then aminopyrine has been used only sporadically and little has been learned about side effects exerted on various organs. In large doses in animals aminopyrine has been reported to cause early oliguria, subsequent polyuria, proteinuria, glycosuria, albuminuria, and hematuria.⁴ The following case is the first report of acute renal failure caused by aminopyrine and calls attention to the need for greater discrimination in the administration of this drug, especially to patients