The Disulfiram (Antabuse)‐Alcohol Reaction in Male Alcoholics: Its Efficient Management by 4‐Methylpyrazole
- 1 September 1981
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 5 (4), 528-530
- https://doi.org/10.1111/j.1530-0277.1981.tb05354.x
Abstract
4-Methylpyrazole (4-MP), an inhibitor of alcchol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an Antabuse-treated alcoholic. 4-MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram-alcohol reactions.This publication has 16 references indexed in Scilit:
- An improved method for the determination of acetaldehyde in human blood with minimal ethanol interferenceClinica Chimica Acta; International Journal of Clinical Chemistry, 1979
- Effect of 4-Methylpyrazole on ethanol elimination rate and hepatic redox changes in alcoholics with adequate or inadequate nutrition and in nonalcoholic controlsMetabolism, 1978
- Acetaldehyde—Its Metabolism and Role in the Actions of AlcoholPublished by Springer Nature ,1978
- Letters To The EditorAlcohol, Clinical and Experimental Research, 1977
- The disulfiram--ethanol reaction: a review.Journal of Studies on Alcohol, 1977
- Lowering of ethanol-derived circulating blood acetaldehyde in rats by D-penicillamineLife Sciences, 1977
- Disulfiram-Induced EncephalopathyArchives of Neurology, 1976
- Toxicity of pyrazole and 4-methylpyrazole in mice and ratsCellular and Molecular Life Sciences, 1972
- DISULFIRAM TREATMENT OF ALCOHOLISM A REVIEWJournal of Nervous & Mental Disease, 1971
- The Role of Acetaldehyde in the Actions of EthanolPublished by Springer Nature ,1971