Puromycin Effect on Memory May Be Due to Occult Seizures
- 21 July 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3786), 333-334
- https://doi.org/10.1126/science.157.3786.333
Abstract
Intracerebral injections of puromycin, which have been shown to impair memory 3 hours after training, increase the susceptibility of mice to seizures after administration of normally subconvulsive doses of pentylenetetrazol. Cycloheximide, which antagonizes the puromycin-induced amnesia 3 hours after training, also antagonizes the puromycin effect on susceptibility to seizure. The anticonvulsant diphenylhydantoin antagonizes the puromycin effect on memory. The puromycin effect on memory may be due to occult seizures.This publication has 5 references indexed in Scilit:
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- Puromycin and Cycloheximide: Different Effects on Hippocampal Electrical ActivityScience, 1966
- Puromycin Effect on Successive Phases of Memory StorageScience, 1966
- Role of the genetic message in polyribosome functionJournal of Molecular Biology, 1965
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