Melatonin, a Pineal Substance: Effect on the Rat Ovary
- 18 July 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 141 (3577), 277-278
- https://doi.org/10.1126/science.141.3577.277
Abstract
Daily injection of microgram amounts of melatonin in rats decreased the incidence of estrus and reduced ovarian weight. Circulating melatonin was selectively taken up and retained by the ovary and pineal gland; this effect was reduced by exposure of rats to constant light. A single injection of melatonin lowered the incidence of estrus among rats exposed to constant light.Keywords
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