The Genetic and Enzymic Regulation of the Synthesis of the a and B Determinants in the Abo Blood Group System
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 10 (2), 83-100
- https://doi.org/10.3109/08820138109050691
Abstract
Possible genetic models for the inheritance of the ABO blood groups are discussed in terms of the glycosyltransferase enzymes which complete the synthesis of the A and B determinants. Recent immunologic evidence in support of the allelic status of the ABO genes is reviewed. Results are presented of experiments which demonstrate that the B gene associated α-3-δ-galactosyltransferase can be used to synthesise blood group A determinants.Keywords
This publication has 21 references indexed in Scilit:
- Human blood group B gene-specified α-3-galactosyltransferase: Purification of the enzyme in serum by biospecific adsorption onto blood group O erythrocyte membranesBiochemical and Biophysical Research Communications, 1977
- Dominance relationships between allelic glycosyltransferase genes in Melandrium: An enzyme-kinetic approachTheoretical and Applied Genetics, 1975
- Carcinoembryonic Antigen and Blood Group Substances in Carcinomas of the Stomach and Colon 2JNCI Journal of the National Cancer Institute, 1974
- Evolution in ActionNature, 1974
- Qualitative Differences in the N -Acetyl-D-galactosaminyltransferases Produced by Human A 1 and A 2 GenesProceedings of the National Academy of Sciences, 1973
- [67] Lactose synthetase (UDP-d-galactose: Accetpor β-4-galactosyltransferase) from bovine milkPublished by Elsevier ,1972
- The Carbohydrate Moiety of the Water-Soluble Human A, B, H, Lea and Leb Substances**Aided by grants from the National Science Foundation (GB-8341), the Office of Naval Research Nonr 266 (13) and the General Research Support Grant of the United States Public Health ServicePublished by Elsevier ,1970
- Unusual Inheritance of ABO Group in a Family with Weak B AntigensVox Sanguinis, 1964
- The Croonian Lecture A contribution to human biochemical genetics ; the chemical basis of blood-group specificityProceedings of the Royal Society of London. B. Biological Sciences, 1960
- Ergebnisse Einer Biostatistischen Zusam-Menfassenden Betrachtung über die Erblichen Blutstrukturen des MenschenKlinische Wochenschrift, 1924