Estrogen-Androgen Antagonism: Histology of Mammary Glands and Vaginal Grafts of Male Mice Receiving Estrogens.

Abstract

1. Studies of the effect of injections of steroid and non-steroid estrogenic substances on the mammary gland and vaginal mucosa of castrate and non-castrate male mice bearing subcutaneous vaginal grafts are reported. 2. It is suggested that antagonistic actions exist between the naturally-occurring estrogens (estrone, estradiol) and testicular androgens in regard to the mammary gland and vaginal mucosa. 3. Such antagonism did not seem to occur when the synthetic estrogenic substance diethylstilbestrol was employed.