The immune response to ?X 174 in man. II. Primary and secondary antibody production in patients with Crohn's disease
- 1 May 1975
- journal article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 20 (5), 430-436
- https://doi.org/10.1007/bf01070787
Abstract
10 patients with Crohn's disease in various states of activity have been injected with 3.3×109 plaque-forming units of the bacteriophage ϕX 174, as a test for their capacity to produce antibodies. 9 patients had a completely normal primary and secondary antibody response. One patient had higher levels of preimmunization antibodies than have been encountered in normal subjects and developed a secondary (IgG) response to the first dose of antigen. We conclude that there is no evidence of a general disturbance of antibody-producing capacity in subjects with Crohn's disease.Keywords
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