Effect of Aspirin Upon Glycosuria of the Partially Depancreatized Rat

Abstract

40, 80, and 160 mg. of aspirin per day was administered to 7 mildly diabetic rats which were force-fed a medium carbohydrate diet. A marked amelioration of the glycosuria together with a gain in weight was noted in each rat. When the drug was withdrawn, there was exacerbation of the glycosuria to significantly higher levels than were noted during the preinjn. period, and there was an accompanying loss of wt.