A defect in inducible β‐galactosidase of B lymphocytes in the osteopetrotic (mi/mi) mouse
- 1 August 1996
- journal article
- Published by Wiley in Immunology
- Vol. 88 (4), 604-610
- https://doi.org/10.1046/j.1365-2567.1996.d01-684.x
Abstract
Macrophages were activated by administration of an inflammatory lipid metabolite, lysophosphatidylcholine (lyso-Pc), to wild type mice but not murine (microphthalmic) osteopetrotic (mi/mi) mutant mice. In vitro treatment of wild type mouse peritoneal cells with lyso-Pc efficiently activated macrophages whereas lyso-Pc-treatment of mi mutant mouse peritoneal cells resulted in no activation of macrophages. Generation of macrophage activating factor requires a precursor protein, serum vitamin D binding protein (DBP), and participation of lyso-Pc-inducible beta-galactosidase of B lymphocytes. Lyso-Pc-inducible beta-galactosidase of B lymphocytes was found to be defective in mi mutant mice.Keywords
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