A FACTOR CAPABLE OF INCREASING VASCULAR PERMEABILITY PRESENT IN LYMPH NODE CELLS - A POSSIBLE MEDIATOR OF DELAYED REACTION

Google Scholar
  • 1 January 1963
    • journal article
    • research article
    • Vol. 6 (5), 484-+
Abstract
A soluble extract from guinea-pig lymph node cells (LPF) has been found to increase vascular permeability in the skin of the rat. The active substance has been differentiated from histamine, 5-hydroxytryptamine, bradykinin, substance P, kallikrein and the globulin permeability factors from rat and guinea-pig serum by means of parallel quantitative assays. LPF was present in both sensitized and non-sensitized guinea-pig lymph node cells and in lymph node cells from rats and mice. LPF also increased vascular permeability in the skin of guinea-pigs, mice and rabbits. The possible importance of this factor in the mechanism of the delayed reactions is discussed.