Regional distribution of putative vasopressin receptors in rat brain and pituitary by quantitative autoradiography.
- 1 November 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (22), 7248-7252
- https://doi.org/10.1073/pnas.81.22.7248
Abstract
Quantitative light microscopic autoradiography was used to map and characterize the distribution of [3H]arginine vasopressin ([3H]AVP) binding sites in the rat brain. HPLC [high pressure liquid chromatography] analysis for possible degradation of AVP during binding indicated that addition of specific peptidase inhibitors prevented metabolism of AVP. Binding sites for [3H]AVP were observed in the hypothalamus and pituitary as well as in brain regions where AVP may act as a neuroregulator. Within the hypothalamus, dense AVP binding sites were seen in the suprachiasmatic, supraoptic and paraventricular nuclei. High specific binding was also apparent in the median eminence tubero-infundibular region and in the posterior lobe of the pituitary. [3H]AVP labeling at possible neuroregulatory sites was observed in the hippocampus, lateral septum, superficial cortex, cerebellum, nucleus tractus solitarius, adenohypophysis and spinal cord.This publication has 31 references indexed in Scilit:
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