The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses

Abstract

We have studied the penetration of aztreonam into pus with a low mortality intra-abdominal abscess model in the Wistar rat. The mean peak serum concentration (standard error) of aztreonam was 74·6 ± 9·88 mg/l at 30 min falling to 2·31±1·28 mg/l at 8h. The mean concentration in pus was 17·04±2·01 mg/l at 2h and was 14·47±2.23 mg/l at 8 h. These concentrations are in excess of the MICs of most Gram-negative aerobic bacilli commonly isolated from intra-abdominal abscesses.