Hair cell degeneration in guinea pigs intoxicated with kanamycin during intrauterine life
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Archives of Oto-Rhino-Laryngology
- Vol. 224 (3-4), 187-191
- https://doi.org/10.1007/bf01108777
Abstract
Es werden die strukturellen ototoxischen Effekte des Kanamycins während der intrauterinen Entwicklung beim Meerschweinchen gezeigt. Es kommt dabei vor allem zu einem Verlust der äußeren Haarzellen in den basalen Anteilen der Schnecke. Ultrastrukturell finden sich ähnliche Degenerationsvorgänge wie bei Antibiotikavergiftung erwachsener Tiere. The structural ototoxic effect of kanamycin during intrauterine life has been shown in guinea pigs. The extent of the loss mostly affected the outer hair cells of the basal part of the cochlea. Ultrastructural studies demonstrated a hair cell degeneration pattern similar to that previously described in adult animals following antibiotic intoxication.Keywords
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