Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease
- 1 August 2007
- Vol. 56 (8), 1171-1173
- https://doi.org/10.1136/gut.2007.122747
Abstract
We have an ongoing genome-wide association study of children with Crohn’s disease using the Illumina Infinium II HumanHap500 BeadChip.5,6 The probe for rs2241880 is present on this platform, so we were able to query our current dataset for its association with Crohn’s disease as a single test. All analyses were carried out using the software package “plink” (http://pngu.mgh.harvard.edu/~purcell/plink/index.shtml). In order to avoid potential bias deriving from population stratification, controls were genetically matched to Caucasian patients with Crohn’s disease by clustering of the pairwise identity-by-state distances. Complete linkage agglomerative clustering was …Keywords
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