Lipoprotein-lipase responses to heparin

Abstract

Recent evidence suggests an interrelationship between platelets, heparin, and the lipolytic enzyme, lipoprotein-lipase. It seems likely that heparin might influence platelet adherence through its activation of lipoprotein-lipase. The mode of activation of the enzyme by heparin may, therefore, be important clinically. In these experiments the enzyme responses to increasing doses of heparin have been measured in dogs. The mean enzyme responses were found to be directly related to the logarithm of the heparin dose.