Effects of Radiation Therapy in Survivors of Wilms's Tumor

Abstract

12 patients surviving live years or longer, of a series of 30 treated for Wilms''s tumor were studied. In all survivors, late tissue changes, skin pigmentation and atrophy, muscle atrophy, and deformities in the ribs, vertebrae, and pelvis were observed. The younger the patient at irradiation and the higher the dose the more severe were the skeletal changes. All postpuberty females had normal menstrual histories and had conceived. Three of these 4 women had a total of 11 normal children.