GLYCOGEN ACCUMULATION IN ALVEOLAR TYPE-II CELLS IN 3-METHYLINDOLE-INDUCED PULMONARY-EDEMA IN GOATS
- 1 January 1981
- journal article
- research article
- Vol. 105 (3), 255-263
Abstract
Infusion [i.v.] 3-methylindole (3MI) induced acute pulmonary edema in goats. Edematous changes were seen in the alveoli and the interalveolar interstitium. At 72 h after treatment, an accumulation of glycogen that had a pathognomonic appearance of alpha particles was observed in the alveolar type II cells. A rich accumulation of glycogen particles and defective lamellar bodies containing triglycerides were the significant morphologic changes in the alveolar type II cells. Apparently, massive glycogen deposition in the alveolar type II cells is a defect that might interfere with surfactant production, further complicating the disease process.This publication has 45 references indexed in Scilit:
- Dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro.1974
- Inactivation of staphylococci by alveolar macrophages with preliminary observations on the importance of alveolar lining material.Published by Elsevier ,1973
- Induction of Pulmonary Edema and Emphysema in Cattle and Goats with 3-MethylindoleScience, 1972
- The role of the pituitary-adrenal-thyroid axes in lung differentiation. I. Studies of the cytology and physical properties of anencephalic fetal rat lung.1972
- Changes in guinea-pig lungs following the inhalation of powdered egg albumenPathology, 1972
- Ultrastructural changes in the alveolar epithelium in response to Freund's adjuvant.1971
- Lipid metabolism by rat lung in vitro. Effect of starvation and re-feeding on utilization of [U-14C]glucose by lung slicesBiochemical Journal, 1971
- Acute bovine pulmonary emphysema in Utah.1971
- The metabolism of glycogen in the lungs of the fetal rabbitDevelopmental Biology, 1965
- IDENTIFICATION AND STRUCTURAL FORMS OF HUMAN PARTICULATE GLYCOGEN1963