Inhibition of lymphocyte activation by hatching fluid from Schistosoma mansoni eggs

Abstract

A preparation of the fluid released upon hatching of the miracidia from Schistosoma mansoni eggs was found to have a potent inhibitory effect on the in vitro activation of hamster lymphocytes by mitogens. The effect was concentration dependent, not cytotoxic, and was the same on cells from healthy and schistosome-infected animals.