Abstract
A high-affinity riboflavin-binding protein was isolated and characterized for the 1st time from pregnant-rat sera by affinity chromatography on a lumiflavin-agarose column. The purified protein was homogeneous by the criteria of analytical disc polyacrylamide-gel electrophoresis [PAGE], gel-filtration chromatography on Sephadex G-100 and sodium dodecyl sulfate/PAGE. It had a MW of 90,000 .+-. 5000 and interacted with [14C]riboflavin with a 1:1 molar ratio with a Kd of 0.42 .mu.M.