THE RELATION OF THE SUPRARENAL CORTICAL HORMONE TO NITROGEN METABOLISM IN EXPERIMENTAL HYPERTHYROIDISM

Abstract

In 2 dogs with one suprarenal gland intact large doses of cortical hormone with injections of thyroxin lessened significantly the breakdown of protein. In 3 bilaterally suprarenalectomized dogs cortical hormone in amts. in excess of that adequate for maintenance diminished, and in some instances prevented, the loss of N which ordinarily occurs after the administration of thyroxin. The rapidity with which N is retained in the presence of large amts. of cortical hormone was demonstrated. Large amts. of cortical hormone lessened the severity and duration of the systemic reaction following the injection of thyroxin. The results uniformly demonstrated that the cortical hormone exerts a sparing action against the effect of thyroxin on N metabolism.