Wnt signalling in stem cells and cancer
Top Cited Papers
- 14 April 2005
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 434 (7035), 843-850
- https://doi.org/10.1038/nature03319
Abstract
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.Keywords
This publication has 87 references indexed in Scilit:
- Frizzled 9 knock-out mice have abnormal B-cell developmentBlood, 2005
- Wnt Activates the Tak1/Nemo-like Kinase PathwayJournal of Biological Chemistry, 2004
- Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitorNature Medicine, 2003
- Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermisDevelopment, 2003
- Identification of the haematopoietic stem cell niche and control of the niche sizeNature, 2003
- Osteoblastic cells regulate the haematopoietic stem cell nicheNature, 2003
- Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancerNature, 2003
- Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signalingNature Genetics, 2002
- Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signallingNature Genetics, 2000
- Gut instincts: thoughts on intestinal epithelial stem cellsJournal of Clinical Investigation, 2000