Effect of Hypercapnia and Hypocapnia on Tryptophan and Tyrosine Hydroxylation in Rat Brain
- 1 April 1977
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 99 (4), 503-509
- https://doi.org/10.1111/j.1748-1716.1977.tb10404.x
Abstract
The effects of induced hypo- and hypercapnia upon the rate of hydroxylation of tryptophan and tyrosine in the rat brain were studied by measuring the accumulation of 5-HTP and DOPA following administration of the aromatic L-aminoacid decarboxylase inhibitor 3-hydroxybenzylhydrazine HC1 (NSD 1015). The results suggest that the hydroxylation of tryptophan varies directly with the tissue Po2- On the other hand, the hydroxylation of tyrosine did not show a simple relationship to Po2 but appeared to be influenced by pH changes.This publication has 19 references indexed in Scilit:
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