Discrimination of Single-Copy IS6110DNA Fingerprints ofMycobacterium tuberculosisIsolates by High-Resolution Minisatellite-Based Typing

Abstract

Seven isoniazid-resistant isolates with mutations in the NADH dehydrogenase (ndh) gene were molecularly typed by IS6110-based restriction fragment length polymorphism analysis. All seven isolates with the R268H mutation had identical 1.4-kb IS6110 fingerprints. High-resolution minisatellite-based typing discriminated five of these isolates; two isolates were identical.