Role of Calclum and Lanatoside C in Increasing Oxygen Consumption in Human Myocardial Tissue Slices

Abstract

1 x 10^-6 M Lanatoside C has been demonstrated to produce a sustained increase in oxygen consumption in human myocardial tissue slices as previously demonstrated by Burdette. This acceleration of qO₂ is independent of the substrates employed with the exception of succinate. This qO₂ acceleration has been demonstrated to be calcium dependent in human heart tissue slices similar to the known interrelationship of calcium and digitalis on myocardial contractility. The observation that the greatest increase in qO₂ occurred with glucose and without exogenous substrate suggests that the increase in qO₂ induced by the glycoside is dependent upon a stimulatory effect on glycolysis.