Photobilirubin: an early bilirubin photoproduct detected by absorbance difference spectroscopy.
Open Access
- 1 January 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (1), 29-32
- https://doi.org/10.1073/pnas.76.1.29
Abstract
Absorption of light converts bilirubin-IX.alpha. in solution to a mixture of what are probably cis-trans geometric isomers. This reaction is much faster than other photochemical reactions of bilirubin and reaches photoequilibrium before losses due to photooxidation are significant. At room temperature in the dark with trifluoroacetic acid or iodine or simply on standing, the photoproducts revert to the natural isomer. They also revert under visible light. Their formation and reversion can be followed by chromatography on polyamide and by absorbance difference spectroscopy. [This may be a key reaction in the phototherapy of neonatal jaundice.].This publication has 10 references indexed in Scilit:
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