Apamin, a nonspecific antagonist of smooth muscle relaxants
- 1 February 1980
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 311 (1), 105-107
- https://doi.org/10.1007/bf00500310
Abstract
Apamin, a peptide of bee venom, was shown to inhibit the relaxant responses of guinea-pig taenia caeci to ATP, noradrenaline, adenosine and, less effectively, to stimulation of noradrenergic inhibitory nerves. Thus apamin acts nonspecifically and, contrary to the suggestion of Vladimirova and Shuba (1978), the fact that inhibitory responses due to nerve stimulation and ATP are blocked by the toxin does not allow conclusions as to the possible transmitter role of ATP in these nerves.Keywords
This publication has 8 references indexed in Scilit:
- The effect of apamin on the smooth muscle cells of the guinea-pig taenia coliEuropean Journal of Pharmacology, 1979
- Effect of strychnine, hydrastine, and apamine on synaptic transmission in smooth muscle cellsNeurophysiology, 1979
- Effect of dipyridamole and 6-(2-hydroxy-5-nitro)-benzylthioguanosine on low-frequency-stimulated relaxation in the guinea pig taenia coliCanadian Journal of Physiology and Pharmacology, 1977
- IDENTIFICATION OF SEPARATE RECEPTORS FOR ADENOSINE AND ADENOSINE 5′‐TRIPHOSPHATE IN CAUSING RELAXATIONS OF THE ISOLATED TAENIA OF THE GUINEA‐PIG CAECUMBritish Journal of Pharmacology, 1976
- TRANSPORT OF NUCLEOSIDES*Annals of the New York Academy of Sciences, 1975
- Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gutBritish Journal of Pharmacology, 1970
- SEQUENZANALYSE DES BIENENGIFT-NEUROTOXINS (APAMIN) AUS SEINEN TRYPTISCHEN UND CHYMOTRYPTISCHEN SPALTSTUCKEN1967
- The structure of apaminChemical Communications (London), 1967