Further Characterization and Evidence for a Precursor in the Formation of Plasma Antinatriferic Factor
- 1 December 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 159 (3), 463-467
- https://doi.org/10.3181/00379727-159-40371
Abstract
Antinatriferic factor was isolated from VE [extracellular fluid volume expanded] dog plasma on high pressure liquid chromatography. The use of an enzyme inhibitor while collecting plasma reduced the presence of this factor. A reverse-phase chromatography peptide map revealed 2 peptides whose presence was directly correlated with antinatriferic activity. Antinatriferic factor is apparently a small acidic peptide, formed from a precursor molecule. Reverse-phase chromatography may prove to be a chemical assay for antinatriferic factor.This publication has 4 references indexed in Scilit:
- Antinatriferic activity in human plasma following acute and chronic salt-loadingKidney International, 1977
- High-efficiency cation-exchange chromatography of polypeptides and polyamines in the nanomale rangeJournal of Chromatography A, 1977
- Two natriuretic substances in extracts of urine from normal man when salt-depleted and salt-loadedKidney International, 1976
- Fluorometric assay of vasopressin and oxytocin: a general approach to the assay of peptides in tissues.Proceedings of the National Academy of Sciences, 1976