Effect of respiratory alkalosis on blood lactate and pyruvate in humans
- 1 March 1967
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 22 (3), 461-468
- https://doi.org/10.1152/jappl.1967.22.3.461
Abstract
Arterial lactate and pyruvate were determined at various levels of hypocapnia and alkalemia in humans during active hyperventilation. Lactate and pyruvate increased in all subjects, and the increases showed an inverse relationship to the decrease in PCO2 a''d H+ concentration. However, even the maximum changes were relatively small, the mean lactate increasing less than 1 mmole/liter H2O at PcO2 = 20 mm Hg, pH = 7.61. Lactate uniformly rose more than pyruvate with consequent rise in lactate/pyruvate ratio. In subjects studied over a period of 2 hr, lactate and pyruvate rose to a peak at 45-75 min*and then declined. In no case was there progressive elevation of lactate or pyruvate nor was there progressive deficit of "true" bicarbonate, ft is concluded that respiratory alkalosis in humans leads neither to large increases in lactate and pyruvate nor to progressive shifts in the buffer curve of the blood. When such increases occur in association with hypocapnia and alkalemia it becomes necessary to invoke some metabolic or circulatory disturbance as a contributing factor,.This publication has 17 references indexed in Scilit:
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