Evaluation of Digoxin Bioavailability in Single-Dose Studies

Abstract

Methods for testing digoxin bioavailability were compared in single-dose crossover studies using eight healthy male subjects. Digoxin (0.75 mg) was given by intravenous infusion, intramuscular injection, oral elixir and oral tablet. Multiple serum concentrations and six-day cumulative urinary excretion were determined after each mode of administration.