Hypolipidemic analogs of ethyl 4-benzyloxybenzoate

Abstract

A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure-activity relationships are discussed in terms of cholesterol-lowering activity together with effects on body weight gain and liver lipids. A number of compounds inhibited cholesterol and free fatty acid biosynthesis from 1-14C-acetate in rat liver slices in vitro. Ethyl-4-benzyloxybenzoate, ethyl-4-benzyloxybenzoic acid, ethyl-4-p-bromobenzyloxybenzoate and ethyl-4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.