Penicillin and Erythromycin Concentrations in Tonsils
- 1 February 1974
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 127 (2), 206-211
- https://doi.org/10.1001/archpedi.1974.02110210056007
Abstract
Penicillin and erythromycin concentrations were measured in sera and tonsils of children undergoing tonsillectomy. For two hours after the intramuscular administration of potassium penicillin G (5,000 units/kg), the levels of penicillin in tonsil were consistently greater than the minimal inhibitory concentrations (MIC) of most group-A, β hemolytic streptococci. Antibiotic was not detected in six of ten specimens obtained four to six hours after single or multiple doses of orally administered phenoxymethyl penicillin. Tonsillar levels of erythromycin were greater than the MIC for group-A, β hemolytic streptococci in eight of ten specimens obtained four to seven hours after single or multiple doses of orally administered erythromycin estolate. Data correlating tonsillar antibiotic levels, MIC values, and in vitro streptococcal kill curves may have relevance to relapse and treatment failures in streptococcal pharyngitis.Keywords
This publication has 11 references indexed in Scilit:
- Influence of Methodology upon Apparent Concentrations of Antibiotics in TissueAntimicrobial Agents and Chemotherapy, 1973
- Streptococcal infections. Masking by oral prophylaxis with penicillinPublished by American Medical Association (AMA) ,1972
- The Role of Tonsils in Predisposing to Streptococcal Infections and Recurrences of Rheumatic FeverNew England Journal of Medicine, 1970
- Significance of theStaphylococcus aureusCarrier State in the Treatment of Disease Due to Group A StreptococciNew England Journal of Medicine, 1964
- Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: III. Comparative Effectiveness of Three Prophylaxis Regimens in Preventing Streptococcal Infections and Rheumatic RecurrencesAnnals of Internal Medicine, 1964
- Streptococcal Pharyngitis TherapyArchives of Pediatrics & Adolescent Medicine, 1964
- ANTAGONISTIC EFFECT OF A PENICILLINASE-PRODUCING STAPHYLOCOCCUS ON PENICILLIN THERAPY OF A STREPTOCOCCAL THROAT INFECTIONThe American Journal of the Medical Sciences, 1962
- IN VITRO ACTIVITY OF VARIOUS PENICILLINSThe American Journal of the Medical Sciences, 1961
- A controlled study of beta hemolytic streptococcal infection in rheumatic families: I. Streptococcal disease among healthy siblingsAmerican Journal Of Medicine, 1958
- The Antibacterial Action of Erythromycin.Experimental Biology and Medicine, 1952