Retrospective analysis of the response of tumours in patients treated with a combination of radiotherapy and hyperthermia

Abstract

One hundred and twelve patients with various carcinomas were treated on 112 fields with radiotherapy and hyperthermia, using non-invasive techniques. Radiotherapy dose ranged from 13–70 Gy (except for one. patient receiving hyperthermia alone) with a mean of 28.6 Gy. The combined treatment was primarily aimed at giving palliation; 79 per cent of the patients had received previous irradiation on the same area. Hyperthermia was given twice weekly following radiotherapy. From the temperature data collected, 12 different parameters expressing the hyperthermia ‘dose’ were derived. The various parameters for both treatment modalities, i.e. radiotherapy and hyperthermia, and some of the tumour parameters were statistically evaluated with respect to their influence on tumour response. The overall response rate was 87 per cent including 33 per cent complete response. The complete response rate increased with increasing radiotherapy total dose, i.e. from 23 per cent (14–25 Gy) and 38 per cent (28–36 Gy) to 60 per cent (> 38 Gy). A positive correlation between the tumour temperature parameter representative of the coldest spot in the tumour, and the level of response was found. Achievement of complete response appeared also to be determined to a considerable extent by radiotherapy total dose as well as tumour volume. The correlation between response level and the minimum hyperthermia dose parameters persisted, however, after correction for the influence of tumour volume and radiotherapy total dose. These results support the opinion that higher tumour response rates can be achieved by increasing the hyperthermia treatment level at the coldest spot in the tumour.