A method for directin vivo measurement of drug concentrations from a single2H NMR spectrum
- 1 March 1989
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 9 (3), 402-410
- https://doi.org/10.1002/mrm.1910090313
Abstract
The use of 2H-labeled drugs provides a measure of drug concentration in situ directly from a single 2H NMR spectrum obtained with any antenna by correcting only for differential saturation effects. The limit of detection for a drug labeled with three equivalent deuterons is roughly 0.5 mM. © 1989 Academic Press, Inc.This publication has 17 references indexed in Scilit:
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