Pharmacologic Studies with Cefaclor, a New Oral Cephalosporin

Abstract

Cefaclor, a new oral cephalosporin, was administered to 18 normal human volunteers in single or multiple doses of 250 and 500 mg. Mean serum concentrations of 6.09 and 12.8 .mu.g/ml were achieved 1 h after single oral doses of 250 and 500 mg, respectively. Serum concentrations declined rapidly and no drug was detected at 4 h. Very high concentrations of cefaclor were found in urine during the 1st 8 h after ingestion of the drug. Of the total dose, 43% was excreted in urine during the 1st 8 h. There was no accumulation of drug in serum during the multiple-dose studies.