Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus
- 1 September 1998
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 9 (13), 3075-3079
- https://doi.org/10.1097/00001756-199809140-00029
Abstract
THE neuroprotective role of 17 β-estradiol in the hippocampal dentate gyrus of adult rats treated with kainic acid has been investigated. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of Nissl-stained and somatostatin-immunoreactive hilar neurons. A single simultaneous systemic dose of estradiol (150 μg per animal) prevented the kainic acid-induced decrease in Nissl-stained and somatostatinergic hilar neurons. These results indicate that estradiol may protect adult hilar neurons in vivo from neurotoxic-induced cell death.Keywords
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