A Note on the Solubility of Progesterone in Aqueous Polyethylene Glycol 400
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 12 (4), 631-635
- https://doi.org/10.3109/03639048609048034
Abstract
The solubility curve of progesterone in aqueous polyethylene glycol (PEG) 400 at ambient room temperature (∼25°C) is bimodal, a break occurring at approximately 60% w/w PEG. It is speculated that the presence of unbound water in the PEG 400/water system depresses the solubility of progesterone in PEG 400 disproportionately.This publication has 4 references indexed in Scilit:
- The interaction of phospholipid membranes with poly(ethylene glycol). Vesicle aggregation and lipid exchangeBiochimica et Biophysica Acta (BBA) - Biomembranes, 1982
- Determination of Aqueous Solubility and pKa Values of EstrogensJournal of Pharmaceutical Sciences, 1977
- Aqueous solubility of steroid hormones: an explanation for the discrepancy in the published dataJournal of Pharmacy and Pharmacology, 1975
- cis- and trans-3-Methylamino-2-phenyltetrahydropyranJournal of Pharmaceutical Sciences, 1972