Presynaptic α-Synuclein Aggregates, Not Lewy Bodies, Cause Neurodegeneration in Dementia with Lewy Bodies
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Open Access
- 7 February 2007
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (6), 1405-1410
- https://doi.org/10.1523/jneurosci.4564-06.2007
Abstract
Lewy bodies, the pathological hallmark of dementia with Lewy bodies (DLB), are large juxtanuclear inclusions of aggregated α-synuclein. However, the small number of cortical Lewy bodies relative to the total neuron count does not correlate with the extent of cognitive impairment. In contrast to dopaminergic neurons in Parkinson's disease, nerve cell loss is usually less prevalent in the cortex of DLB, suggesting a different mechanism of neurodegeneration.Keywords
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