Normal human sleep: Regional cerebral hemodynamics
- 1 May 1980
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 7 (5), 471-478
- https://doi.org/10.1002/ana.410070514
Abstract
Measurements of regional cerebral blood flow (rCBF) by the xenon 133 inhalation method along with polygraph recordings were made serially during relaxed wakefulness and different stages of nocturnal sleep in 18 righthanded normal volunteers. During stage I‐II sleep the fast flow (Fg) values declined significantly, more in the brainstem‐cerebellar (BSC) regions than in hemispheric regions. During stage III‐IV sleep, Fg further declined diffusely in both hemispheric (‐28%) and BSC (‐29%) regions. Duringg awakening from stage IV sleep to alpha‐frequency wakefulness, BSC flow values increased more than hemispheric flow values. During REM sleep, regional Fg values increased diffusely in both hemispheric (+41%) and BSC (+47%) regions compared with wakefulness. There was a significant inverse correlation between the increase in end‐tidal partial pressure for carbon dioxide and the reduction in bihemispheric Fg during sleep. Cerebral vasomotor responsiveness to carbon dioxide is decreased during both REM and non‐REM sleep.Keywords
This publication has 32 references indexed in Scilit:
- Critical appraisal of cerebral blood flow measured from brain stem and cerebellar regions after 133 Xe inhalation in humans.Stroke, 1979
- 133Xe inhalation method for measuring cerebral blood flow in conscious baboons.Stroke, 1979
- Improved method for noninvasive measurement of regional cerebral blood flow by 133Xenon inhalation. Part I: description of method and normal values obtained in healthy volunteers.Stroke, 1978
- Cerebral hypnogenic centersAnnals of Neurology, 1977
- Aspects of the Cerebral Circulation During Non-REM Sleep in Healthy Controls and Psychiatric Patients, as Shown by RheoencephalographyPsychophysiology, 1975
- Regional Cerebral Blood Flow Estimated by 133 Xenon InhalationStroke, 1975
- Rapid eye movement (REM) sleep deprivation, stress and intermediary metabolismJournal of Neurochemistry, 1974
- Regional blood flow in the normal cerebral hemisphere.Journal of Neurology, Neurosurgery & Psychiatry, 1969
- THE EFFECT OF SLOW WAVE SLEEP AND REM SLEEP ON REGIONAL CEREBRAL BLOOD FLOW IN CATS*Journal of Neurochemistry, 1968
- THE EFFECTS OF SLEEP AND LACK OF SLEEP ON THE CEREBRAL CIRCULATION AND METABOLISM OF NORMAL YOUNG MEN 1JCI Insight, 1955