Development of Experimental Renal Hypertension in the Dog Following Reduction of Renal Artery Pulse Pressure Without Reducing Mean Pressure

Abstract

Exptl. renal hypertension may be produced in the dog by reduction of arterial pulse pressure at the renal artery. Reduction of renal artery pulse pressure apparently causes a decrease in intrarenal volume pulsation which may serve as a basic stimulus for hypertension development in dogs. The abdominal aorta was constricted above the left renal artery in 5 right nephrectomized and 2 normal dogs, by the application of a Gold-blatt-type clamp. The degree of constriction was such as to reduce femoral arterial pulse pressure without reduction of mean pressure. A significant rise in mean arterial pressure occurred in 6 of the 7 dogs 24-48 hrs. postoperatively. These dogs remained hypertensive throughout the postoperative period of study. Suitable control studies were made in other dogs.