Preparation and evaluation of gelatin microcapsules of sulfonamides.

Abstract

A simple microencapsulation of 3 sulfonamides (sulfanilamide, sulfisomidine and sulfamethizole) was investigated. The preparation is based on dispersion of a gelatin-sulfonamide mixture in liquid paraffin, followed by drying and hardening with formalin-isopropanol treatment. The microcapsules were recovered as a discrete, free-flowing powder with a particle diameter of 250-840 .mu.m. Dissolution of sulfamethizole from microcapsules approximated a zero-order release pattern from 0 to 10-30% dissolution. These microcapsules may be useful for studies related to sustained-release formulation.