Effects of Platinum Antitumor Agents on in vitro Assays of Human Antitumor Immunity
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 26 (1), 1-6
- https://doi.org/10.1159/000237876
Abstract
The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines [CCRF-CEM, CCRF-HSB-2, CCRF-SB, RMPI-7666] mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted in a small but significant enhancement of target cell lysis. Pretreatment of target cell lines with 5 .mu.M cis-[Pt(NH3)2Cl2] also resulted in a similar increase in target cell susceptibility to lysis.Keywords
This publication has 4 references indexed in Scilit:
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- Spontaneous cytotoxicity of human lymphoblast cell lines mediated by normal peripheral blood lymphocytesCellular Immunology, 1977
- Culture of normal human leukocytesJAMA, 1967
- Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemiaCancer, 1965