Rhesus Monkeys (Macaca mulatta) as a Model For Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
- 1 February 1986
- journal article
- research article
- Published by Wiley in Journal of Medical Primatology
- Vol. 15 (1), 11-16
- https://doi.org/10.1111/j.1600-0684.1986.tb00186.x
Abstract
Calcium pyrophosphate dihydrate crystal deposition disease (CPDD) was recognized in 4 of 30 free‐ranging rhesus macaques. By means of tissue radiography, focal radiodensities were noted in lumbar intervertebral discs, menisci, and articular cartilage. Crystal deposits were identified as calcium pyrophosphate dihydrate (Ca2P2O7·2H2O) by means of X‐ray diffraction. The pathogenesis of calcium pyrophosphate dihydrate arthropathy in man remains elusive. However, with the recognition of this arthritis in a well defined population of aged nonhuman primates, a model now exists to facilitate the study of this disease.Keywords
This publication has 7 references indexed in Scilit:
- Calcium Pyrophosphate Deposition in Nonhuman PrimatesVeterinary Pathology, 1984
- Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Concurrent Vertebral Hyperostosis in a Barbary ApeArthritis & Rheumatism, 1983
- The effects of intraarticular corticosteroids on articular cartilageSeminars in Arthritis and Rheumatism, 1981
- Aging and Degeneration in the Lumbar Intervertebral DiscOrthopedic Clinics of North America, 1977
- Articular Chondrocalcinosis, Hydroxyapatite Deposition Disease, in Adult Mature RabbitsJournal of Bone and Joint Surgery, 1972
- Calcinosis Circumscripta (Calcium Gout) in related Irish WolfhoundsJournal of Small Animal Practice, 1967
- Calcium Gout (Kalkgicht) and Calcinosis Circumscripta in DogsBritish Veterinary Journal, 1960