In-vitro activity of cefotetan, other -lactams and netilmicin

Abstract

In-vitro activity of cefotetan was compared to that of other cephalosporins and netilmicin. Cefotetan at very low concentrations inhibited Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens . Poor activity was seen for all β-lactams against Enterobacter and Citrobacter spp. Activity of cefotetan against Staphylococcus aureus was comparable to that of ccftazidime and moxalactam. Netilmicin was the only agent equally active against all Gram-negative bacilli and Staph. aureus tested. Under conditions simulating serum levels cefotetan demon–strated rapid and long–acting bactericidal activity and bacteria exposed to these concentrations required up to 10.2 h to recover from the effect of the antibiotic. Six out of 15 strains did not recover fully.