Urinary Estrogen Excretion in Men with Breast Cancer

Abstract

IN 1942 Farrow and Adair¹ reported rapid progression of osseous metastases as a result of treatment with testosterone propionate in a male patient with cancer of the breast. In a second male patient, also with osseous metastases from an inoperable breast cancer, these authors performed a bilateral orchiectomy and obtained definite regression of the cancer, including marked decrease in the size of the ulcerative lesion of the breast, calcification of osteolytic bone metastases and complete relief of bone pain. The authors measured the urinary excretion of "estrogenic substance" and 17-ketosteroid before and after treatment and found a marked decrease in . . .